1,106 research outputs found
Trends and characteristics of accidental and intentional codeine overdose deaths in Australia
Examines trends in codeine-related mortality rates in Australia, and the clinical and toxicological characteristics of codeine-related deaths.
Abstract
Objectives: To examine trends in codeine-related mortality rates in Australia, and the clinical and toxicological characteristics of codeine-related deaths.
Design and setting: Analysis of prospectively collected data from the National Coronial Information System on deaths where codeine toxicity was determined to be an underlying or contributory cause of death. The study period was 2000â2013.
Main outcome measures: Population-adjusted numbers (per million persons) of (1) codeine-related deaths, classified by intent (accidental or intentional); and (2) heroin- and Schedule 8 opioid-related deaths (as a comparator).
Results: The overall rate of codeine-related deaths increased from 3.5 per million in 2000 to 8.7 per million in 2009. Deaths attributed to accidental overdoses were more common (48.8%) than intentional deaths (34.7%), and their proportion increased during the study period. High rates of prior comorbid mental health (53.6%), substance use (36.1%) and chronic pain (35.8%) problems were recorded for these deaths. For every two Schedule 8 opioid-related deaths in 2009, there was one codeine-related death. Most codeine-related deaths (83.7%) were the result of multiple drug toxicity.
Conclusions: Codeine-related deaths (with and without other drug toxicity) are increasing as the consumption of codeine-based products increases. Educational messages are needed to better inform the public about the potential harms of chronic codeine use, especially in the context of polypharmacy
Searching for Planets in the Hyades II: Some Implications of Stellar Magnetic Activity
The Hyades constitute a homogeneous sample of stars ideal for investigating
the dependence of planet formation on the mass of the central star. Due to
their youth, Hyades members are much more chromospherically active than stars
traditionally surveyed for planets using high precision radial velocity (RV)
techniques. Therefore, we have conducted a detailed investigation of whether
magnetic activity of our Hyades target stars will interfere with our ability to
make precise RV searches for substellar companions. We measure chromospheric
activity (which we take as a proxy for magnetic activity) by computing the
equivalent of the R'HK activity index from the Ca II K line. is not
constant in the Hyades: we confirm that it decreases with increasing
temperature in the F stars, and also find it decreases for stars cooler than
mid-K. We examine correlations between simultaneously measured R'HK and RV
using both a classical statistical test and a Bayesian odds ratio test. We find
that there is a significant correlation between R'HK and the RV in only 5 of
the 82 stars in this sample. Thus, simple Rprime HK-RV correlations will
generally not be effective in correcting the measured RV values for the effects
of magnetic activity in the Hyades. We argue that this implies long timescale
activity variations (of order a few years; i.e., magnetic cycles or growth and
decay of plage regions) will not significantly hinder our search for planets in
the Hyades if the stars are closely monitored for chromospheric activity. The
trends in the RV scatter (sigma'_v) with , vsini, and P_rot for our stars
is generally consistent with those found in field stars in the Lick planet
search data, with the notable exception of a shallower dependence of sigma'_v
on for F stars.Comment: 15 pages, 7 figures, 3 tables; To appear in the July 2002 issue of
The Astronomical Journa
The supercluster--void network III. The correlation function as a geometrical statistic
We investigate properties of the correlation function of clusters of galaxies
using geometrical models. On small scales the correlation function depends on
the shape and the size of superclusters. On large scales it describes the
geometry of the distribution of superclusters. If superclusters are distributed
randomly then the correlation function on large scales is featureless. If
superclusters and voids have a tendency to form a regular lattice then the
correlation function on large scales has quasi-regularly spaced maxima and
minima of decaying amplitude; i.e., it is oscillating. The period of
oscillations is equal to the step size of the grid of the lattice.
We calculate the power spectrum for our models and compare the geometrical
information of the correlation function with other statistics. We find that
geometric properties (the regularity of the distribution of clusters on large
scales) are better quantified by the correlation function. We also analyse
errors in the correlation function and the power spectrum by generating random
realizations of models and finding the scatter of these realizations.Comment: MNRAS LaTex style, 12 pages, 7 PostScript figures embedded, accepted
by MNRA
Time-independent approximations for periodically driven systems with friction
The classical dynamics of a particle that is driven by a rapidly oscillating
potential (with frequency ) is studied. The motion is separated into a
slow part and a fast part that oscillates around the slow part. The motion of
the slow part is found to be described by a time-independent equation that is
derived as an expansion in orders of (in this paper terms to the
order are calculated explicitly). This time-independent equation
is used to calculate the attracting fixed points and their basins of
attraction. The results are found to be in excellent agreement with numerical
solutions of the original time-dependent problem.Comment: 5 pages, 4 figures. Revised version. Minor change
The periodic variations of a white-light flare observed with ULTRACAM
High time resolution observations of a white-light flare on the active star EQ PegB show evidence of intensity variations with a period of â10 s. The period drifts to longer values during the decay phase of the flare. If the oscillation is interpreted as an impulsively-excited,
standing-acoustic wave in a flare loop, the period implies a loop length of â3.4 Mm and â6.8 Mm for the case of the fundamental mode and the second harmonic, respectively. However, the small loop lengths imply a very high modulation depth making the acoustic interpretation unlikely. A more realistic interpretation may be that of a fast-MHD wave, with the modulation of the emission being
due to the magnetic field. Alternatively, the variations could be due to a series of reconnection events. The periodic signature may then arise as a result of the lateral separation of individual flare loops or current sheets with oscillatory dynamics (i.e., periodic reconnection)
Photospheric and chromospheric activity in four young solar-type stars
We present a photometric and spectroscopic study of four G-K dwarfs, namely
HD 166, epsilon Eri, chi1 Ori and kappa1 Cet. In three cases, we find a clear
spatial association between photospheric and chromospheric active regions. For
chi1 Ori we do not find appreciable variations of photospheric temperature, and
chromospheric Halpha emission. We applied a spot/plage model to the observed
rotational modulation of temperature and flux to derive spot/plage parameters
and to reconstruct a rough three-dimensional map of the outer atmosphere of
kappa1 Cet, HD 166 and epsilon Eri.Comment: 12 pages, 3 tables, 9 figures. Submitted to Ap
An integrative approach based on probabilistic modelling and statistical inference for morpho-statistical characterization of astronomical data
This paper describes several applications in astronomy and cosmology that are
addressed using probabilistic modelling and statistical inference
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